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Cancer discoveryJournal Article

07 May 2025

Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment.

Abstract

Our comprehensive analysis of ecDNA in urothelial carcinoma reveals its crucial role in driving the evolution and heterogeneity of multifocal cancer, as well as its early involvement in tumorigenesis.

Moreover, this study sheds light on immune evasion mechanisms associated with ecDNA and offers valuable insights for developing targeted therapeutic strategies.

Article info

Journal issue:

  • Volume: not provided
  • Issue: not provided

Doi:

10.1158/2159-8290.CD-24-1532

More resources:

Silverchair Information Systems

Full Text Sources

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