Unleashing the Full Potential of Metabolic Interventions in T-ALL.

Abstract

Drugs targeting metabolism have been effectively used in patients with T-cell acute lymphoblastic leukemia (T-ALL) for decades; still, the full therapeutic potential of targeting metabolism has not been completely exploited yet.

Here, we highlight the critical need for metabolic biomarkers to advance precision medicine in T-ALL, explore the identification of novel metabolic vulnerabilities, and discuss the potential of targeted therapies and dietary interventions to optimize treatment outcomes.

COI Statement

D. Herranz reports grants from NIH/NCI grants R01CA285513 and R01CA236936, The Leukemia & Lymphoma Society Scholar Award 1386-23, The V Foundation Pediatric Translational Grant T2023-024, the Alex’s Lemonade Stand Foundation R Accelerated Award 23-28273, and grants from the Ludwig Cancer Research Princeton Branch. No disclosures were reported by the other author.

References:

Pagliaro L, Chen SJ, Herranz D, Mecucci C, Harrison CJ, Mullighan CG, et al. . Acute lymphoblastic leukaemia. Nat Rev Dis Primers 2024;10:41.
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, et al. . The genomic basis of childhood T-lineage acute lymphoblastic leukaemia. Nature 2024;632:1082–91.
Rashkovan M, Albero R, Gianni F, Perez-Duran P, Miller HI, Mackey AL, et al. . Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in early T-cell precursor acute lymphoblastic leukemia. Cancer Discov 2022;12:856–71.
Bartman CR, Faubert B, Rabinowitz JD, DeBerardinis RJ. Metabolic pathway analysis using stable isotopes in patients with cancer. Nat Rev Cancer 2023;23:863–78.
Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, Tosello V, et al. . Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med 2015;21:1182–9.

Article info

Journal issue:

Volume: 6
Issue: 3

Doi:

10.1158/2643-3230.BCD-25-0012

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Unleashing the Full Potential of Metabolic Interventions in T-ALL.

Abstract

COI Statement

References:

Pagliaro L, Chen SJ, Herranz D, Mecucci C, Harrison CJ, Mullighan CG, et al. . Acute lymphoblastic leukaemia. Nat Rev Dis Primers 2024;10:41.
Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, et al. . The genomic basis of childhood T-lineage acute lymphoblastic leukaemia. Nature 2024;632:1082–91.
Rashkovan M, Albero R, Gianni F, Perez-Duran P, Miller HI, Mackey AL, et al. . Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in early T-cell precursor acute lymphoblastic leukemia. Cancer Discov 2022;12:856–71.
Bartman CR, Faubert B, Rabinowitz JD, DeBerardinis RJ. Metabolic pathway analysis using stable isotopes in patients with cancer. Nat Rev Cancer 2023;23:863–78.
Herranz D, Ambesi-Impiombato A, Sudderth J, Sánchez-Martín M, Belver L, Tosello V, et al. . Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med 2015;21:1182–9.