Subtypes of tumor-associated neutrophils and their roles in cancer immunotherapy.

Abstract

Neutrophils are essential components of the innate immune system. Tumor-associated neutrophils (TANs) are shaped by tumor microenvironment (TME), leading to significant heterogeneity in biological characteristics and functions.

Recent advances in single-cell sequencing have revealed a wide array of TAN subtypes, while a comprehensive classification system is still lacking.

This review aims to summarize the alterations observed in TAN subgroups following cancer immunotherapy, and identify the distinctions and commonalities between pro-tumor and anti-tumor subgroups.

Current progress of preclinical and clinical studies is also highlighted, involving novel therapies targeting TANs.

COI Statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Reports a relationship with that includes:. Has patent pending to. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Article info

Journal issue:

Volume: not provided
Issue: not provided

Doi:

10.1016/j.critrevonc.2025.104763

More resources:

Elsevier Science

Full Text Sources

Paid

ClinicalKey

Full Text Sources

Paid