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Intensive care medicineEditorial

05 May 2025

Carbon dioxide pathophysiology and targets following acute brain injury.

No abstract available

COI Statement

Declarations. Conflicts of interest: CR reports fees as speaker from BD. The other authors have no COI.

References:

  • Smith AL, Neufeld GR, Ominsky AJ, Wollman H (1971) Effect of arterial CO 2 tension on cerebral blood flow, mean transit time, and vascular volume. J Appl Physiol 31:701–707
  • Hoiland RL, Robba C, Menon DK, Citerio G, Sandroni C, Sekhon MS (2023) Clinical targeting of the cerebral oxygen cascade to improve brain oxygenation in patients with hypoxic-ischaemic brain injury after cardiac arrest. Intensive Care Med 49:1062–1078
  • Willie CK, Tzeng YC, Fisher JA, Ainslie PN (2014) Integrative regulation of human brain blood flow. J Physiol 592:841–859
  • Marion DW, Puccio A, Wisniewski SR, Kochanek P, Dixon CE, Bullian L, Carlier P (2002) Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury. Crit Care Med 30:2619–2625
  • Coles JP, Minhas PS, Fryer TD, Smielewski P, Aigbirihio F, Donovan T, Downey SP, Williams G, Chatfield D, Matthews JC, Gupta AK, Carpenter TA, Clark JC, Pickard JD, Menon DK (2002) Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates. Crit Care Med 30:1950–1959

Article info

Journal issue:

  • Volume: not provided
  • Issue: not provided

Doi:

10.1007/s00134-025-07913-1

More resources:

Springer

Full Text Sources

Paid

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